Clinical Pharmacokinetics Intern at Incyte

IMPORTANT INFORMATION BEFORE STARTING YOUR APPLICATION:

1. This internship position is part of the University of Delaware’s Accelerate to Industry (A2i) program. It is meant to complement research training for full-time graduate students pursuing a graduate degree in STEM, humanities, and social sciences at the University of Delaware. 
2. INTERNATIONAL STUDENTS: Please consult ISSS before applying to this role. Only submit an application if you are eligible for CPT. 
3. For each A2i internship application, candidates must also complete this form by the application deadline.
4. Upload your application materials as Word documents
5. Please name your resume “[Last name]_Resume_[Position title]” where [Position title] is the title of the specific fellowship opportunity e.g. Ramos_Resume_DEI Analyst
6. Please make sure to follow job application conventions in the United States. For example, do not include your personal information (birthdate, social security number, student ID number, etc.) or your photograph in the application.
7. If the position requires a transcript, please provide your current University of Delaware transcript.
8. For additional documents that may be required for some A2i internship positions, please combine the information (e.g. list of professional references, writing samples, etc) into a single document. Applicants will not be able to upload more than the required number of documents in Handshake. Use the “[Last name]_Additional_[Position title]” naming convention to name your document.
9. Once your application documents are submitted in Handshake, it is not possible to modify your documents. Please review carefully before submission. If you have questions, please email gradsuccess@udel.edu before submitting your application.
10. If selected for the internship, you will be expected to be registered and enrolled in the GRCO 664 graduate internship course for 1-credit during the duration of the internship.

Clinical Pharmacokinetics Intern at Incyte

Priority application deadline - January 31, 2024 at 11:55 p.m. Eastern  

Mission and goals of the sponsoring organization

Incyte is a biopharmaceutical company focused on the discovery, development, and commercialization of novel medicines to meet serious unmet medical needs in oncology and inflammation and autoimmunity. Incyte is committed to the rigorous pursuit of research and development excellence to improve the lives of patients, make a difference in health care, and build sustainable value. The Company strives to discover and develop first-in-class and best-in-class medicines-advancing a diverse portfolio of large and small molecules.

Incyte is looking for a graduate student intern to join Incyte as a Physiologically Based Pharmacokinetics (PBPK) Modeler where you will support global drug development by building models in different therapeutic areas with a focus on oncology and inflammatory diseases. You will also collaborate with clinical pharmacology, clinical research, nonclinical drug safety, drug discovery, drug metabolism and translational medicine. Being responsible for implementing the right modeling & simulation strategy to assist with drug development, establishing PK/PD relationships and creating mechanistic pharmacology/toxicology models, you can help advance projects more efficiently.

Responsibilities: the intern will participate in building PBPK models for drug discovery projects:

• Interface between clinical pharmacology, clinical research, nonclinical drug safety, drug discovery, drug metabolism, translational medicine and pharmacovigilance to influence drug development.
• Work with cross-disciplinary teams, evaluating complex information to identify key scientific questions related to projects.
• Analyze and interpret preclinical and clinical data. Conduct research/data analysis to understand the effects of healthy and disease states on drug absorption, distribution, and elimination.
• Design and build PBPK and mechanistic models to assist with safety margin selection, study design and biomarker selection, including (but not limited to) first in human (FIH) predictions, formulation design/optimization, population simulations, and DDI predictions.
• Communicate actionable output of modeling work to audiences in cross-disciplinary teams.
• Present work at conferences, internal meetings, etc.

Desired characteristics of applicants

• Currently enrolled UD Master’s or PhD graduate students in science or engineering disciplines including but not limited to chemical or biomedical engineering, pharmaceutical sciences, physics, mathematics, statistics or related fields with training in mathematical modeling of biological systems. 
• Strong competency in learning and running PBPK modeling and simulation related software such as GastroPlus, SimCyp, PKSim, R and Matlab/SimBiology.
• Must enjoy learning novel biology and technologies, as well as working in an interdisciplinary environment. 
• Ability to prioritize and manage multiple projects while meeting project deadlines.
• Experience in physiology, PBPK/PD modeling and simulation, and good knowledge of the scientific literature in the field is highly desired. 

Mentoring Plan: The intern will be mentored by the director of clinical pharmacokinetics 

Internship duration is up to 6 months and depending on the intern’s availability with a start date in February 2024

Internship format: In-person 

Estimated time commitment: 40 hours per week, depending on the student’s availability